Mohammadreza Armanmehr and Sayede Ava Reieesi
In recent years, skin medicines have had side effects. Every day, with the spread of disease, drugs need to be synthesized with new formulations. In recent years, it has been proven that the small size of a drug is directly related to penetration into the branchial layer of the skin. On the other hand, the anti-inflammatory properties of aspirin and bromelain enzymes led to the development of new skin drugs with anti-inflammatory properties. For this purpose, for synthesis, we added 10 mg of aspirin to 50 ml of distilled water at room temperature on a stirrer for 30 minutes. Then, we added 1 mg of bromelain to the previous solution and put it on the stirrer again. We put the sample in an autoclave for 16 hours at a temperature of 180 degrees Celsius, passed it through a strainer and washed it. The above method is one of the methods of doping. After that, the desired material was subjected to SEM analysis to determine its size with a fine ball mill. Then, the roughness, smoothness and average particle size were evaluated with ImageJ software. The purpose of preparing these micromedicines is for skin treatment purposes.