International Journal of Oral Health Dental Management
- ISSN: 2577-6533
Dito Anurogo
Epitranscriptomics, the study of RNA modifications and editing, has emerged as a promising field in dental disorders management. This comprehensive review explores its multifaceted role in gene regulation and potential applications in dentistry. The overview highlights the significance of epitranscriptomics in cellular functions and gene regulation. Mechanisms of RNA modifications, such as RNA methylation and N6-methyladenosine (m6A), impacting dental pathophysiology and enamel formation are discussed, as well as the importance of RNA editing in dental anomalies and periodontal diseases. Epitranscriptomic biomarkers, including m6A and A-to-I editing, offer non-invasive approaches for dental caries detection, while non-coding RNAs may predict dental diseases. Targeting RNA modifications for dental tissue regeneration and personalized RNA editing-based gene therapies hold potential for precision dentistry. Challenges and future perspectives encompass technological improvements, ethical considerations, and the exciting prospects of personalized epitranscriptomic dental medicine. As research progresses, epitranscriptomic therapies offer new horizons in dental care, revolutionizing diagnostics, treatment, and preventive strategies, leading to improved oral health outcomes and patient-centered dental care