International Journal of Diabetes its Complications
- ISSN: 2573-8895
Mehmet Rami Helvaci, Valeria Pappel, Kubra Piral, Mehpare Camlibel, Huseyin Sencan, Ramazan Davran, Mustafa Yaprak, Abdulrazak Abyad and Lesley Pocock
Background: The hardened red blood cells (RBCs)-induced capillary endothelial damage initiates at birth in sickle cell diseases.
Methods: Patients with RBCs transfusions of less than 50 units in their lives were put into the first and 50 units or higher were put into the second groups.
Results: There were 224 and 92 patients in the first and second groups, respectively. Mean ages were similar in them (28.9 vs 30.0 years, respectively, p>0.05). Although the lower prevalence of autosplenectomy (56.2% vs 45.6%, p<0.05), male ratio (45.5% vs 64.1%, p<0.001), white blood cells (WBCs) (14.931 vs 15.346/μL, p<0.05) and platelets (PLTs) (435.670 vs 498.310/μL, p= 0.005) counts, painful crises per year (3.8 vs 8.4, p= 0.000), smoking (12.0% vs 17.3%, p<0.05), clubbing (7.1% vs 15.2%, p<0.01), chronic obstructive pulmonary disease (COPD) (6.6% vs 20.6%, p<0.001), leg ulcers (11.6% vs 21.7%, p<0.01), stroke (5.8% vs 11.9%, p<0.05), chronic renal disease (CRD) (4.9% vs 14.1%, p<0.001), and coronary heart disease (CHD) (4.0% vs 8.6%, p<0.05) were higher in the second group, and mean age of mortality was lower in males (29.7 vs 33.3 years, p<0.05).
Conclusion: Although the lower prevalence of autosplenectomy, male ratio, WBCs and PLTs counts, painful crises per year, smoking, clubbing, COPD, leg ulcers, stroke, CRD, and CHD were higher in the second group, and mean age of mortality was lower in males. So autosplenectomy may be a good, and male gender alone may be a bad prognostic feature that can not be explained by smoking alone at the younger age.