Journal of Cancer Research
- ISSN: 2578-3726
Alexandre Tavartkiladze, Gaiane Simonia, Dinara Kasradze, Nana Okrostsvaridze, Pati Revazishvili, Maia Maisuradze, Irine Andronikashvili, Givi Tavartkiladze, George Dundua, David Egiazarov, Shota Gabadadze, Tatia Potskhoraia, Tamar Japaridze and Tamaz Mamukishvili
Objective: This study aims to evaluate the biochemical and clinical parameters in patients exhibiting symptoms of probable post-COVID syndrome, including general weakness, musculoskeletal pain, severe dyslipidemia, functional nervous system changes, increased oncological disease frequency, and arterial hypertension.
Methods: A total of 102 patients with a history of COVID-19 infection and the aforementioned symptom complex were included in the study. Blood plasma and urine samples were analyzed for melatonin, melatonin sulfate, serotonin, TNFalpha, interleukin-6, interleukin-8, serum amyloid A, BNP, squalene, homocysteine, endothelin, and prostacyclin. The results were compared with a control group of 70 practically healthy patients of the same age group (23-77 years old) who did not exhibit these symptoms.
Results: The study found significant alterations in various biochemical parameters in the patient group compared to the control group. Key findings include a sharp decrease in melatonin (15.4 ± 2.1 ng/mL vs. 40.2 ± 3.2 ng/mL) and melatonin sulfate (45.3 ± 5.6 μg/24h vs. 130.4 ± 7.1 μg/24h), moderate decreases in serotonin (120.4 ± 10.5 ng/mL vs. 190.7 ± 12.3 ng/mL), and increases in TNF-alpha (8.2 ± 1.4 pg/mL vs. 3.6 ± 0.9 pg/mL), interleukin-6 (75.3 ± 6.8 pg/mL vs. 6.2 ± 0.7 pg/mL), interleukin-8 (20.4 ± 2.1 pg/mL vs. 8.5 ± 1.0 pg/mL), serum amyloid A (15.7 ± 3.2 μg/mL vs. 5.6 ± 1.3 μg/mL), BNP (90.5 ± 12.7 pg/mL vs. 30.3 ± 5.2 pg/mL), and homocysteine (25.4 ± 3.6 μmol/L vs. 10.5 ± 1.7 μmol/L). Additionally, a sharp decrease in squalene (1.2 ± 0.3 μg/mL vs. 6.8 ± 1.0 μg/mL) and moderate increases in endothelin (4.8 ± 0.6 pg/ mL vs. 2.3 ± 0.5 pg/mL) and prostacyclin (120.3 ± 15.6 pg/mL vs. 45.7 ± 6.4 pg/mL) were observed.
Conclusion: The biochemical imbalances observed in the post-COVID syndrome patients suggest a multifaceted impact on metabolic and inflammatory pathways, potentially contributing to the observed symptomatology. Further research is needed to explore targeted therapeutic interventions.