Dr. Vishal Chandra, Dr. (Mohd.) Tashfeen Ashraf, Pramod Yadav, and Vikas Raghuvanshi
Background: Osteoarthritis (OA) is a prevalent and debilitating joint disorder with complex etiology, leading to substantial morbidity worldwide. This study aimed to provide a comprehensive and integrative analysis of the clinical and serological features of OA, focusing on primary knee OA as a representative model.
Methods: A large and diverse cohort of 100 OA patients and 120 healthy controls from India were recruited and subjected to rigorous assessments, including radiological, clinical, functional, and biochemical measurements. Serological evaluations encompassed the quantification of creatinine, uric acid, lipids, and MDA as markers of lipid peroxidation and oxidative stress. Additionally, antioxidant enzyme activities, CRP levels, and inflammatory markers were assessed.
Results: Statistical analyses revealed significant differences between OA patients and controls, indicating dyslipidemia and increased oxidative stress in OA. Furthermore, significant correlations between some parameters and OA severity or pain scores were found, suggesting potential prognostic roles.
Conclusion: This study provides valuable insights into the clinical and serological features of OA, highlighting the potential for novel biomarkers and personalized interventions for OA management and prevention.