Journal of Gynecology and Reproductive Health
- ISSN: 2574-2728
Kadir Guzin, Alev Ã?zer, Huri Nigar Å?ahpaz KurÅ?un, Adem Doganer and Mustafa Demir
Objectives: It was aimed evaluate the benefit of colposcopic examination in the determination of cervical intraepithelial neoplasia (CIN) 2 and above lesions (CIN2+) including CIN2, CIN3, and cervical cancer in cases with high-risk HPV types other than HPV 16 and 18, and having normal Pap smear cytology results in national screening programme.
Methods: Group 1 (n:128) was formed of cases with either HPV 16 and/or 18 positive, with/without other high-risk HPVs. Group 2 (n:149) included cases determined as positive only for other high-risk HPV types without HPV 16 and/or 18. All participants underwent colposcopic examination.
Results: In a total of 98 cases determined with CIN2+ lesions on colposcopy, 51 cases (52.0%) were reported as normal cytology, and 47 (48%) cases as abnormal cytology in the Pap smear results. In cases with normal Pap smear screening, the detection rates of CIN2+ on colposcopy were 36.8 and 19.5% in Groups 1 and 2 respectively (p=0.026).The Pap smear screening was determined to have sensitivity of 42.6% specificity of 81.1% positive predictive value of 4.0, and negative predictive value of of 98.7%.Malignancy was determined in a total of 7 patients (5 in Group 1, 2 in Group 2.
Conclusions: Routine application of colposcopy not only to HPV 16 and 18 but also to other high-risk HPV types, with normal Pap smear screening could contribute to increasing the detection rates of high risk lesions. The findings of the current study could be useful to revise guidelines related to cervical cancer screening