Nitaswini Dutta, Sarmistha Ray
Selenium is a vital micronutrient essential for the health of humans, animals, and microorganisms. Recently, there has been a growing interest among researchers in selenium nanoparticles (SeNPs) due to their biocompatibility, bioavailability, and low toxicity. The increased bioactivity of selenium nanoparticles has led to their widespread use in various biomedical applications. While selenium nanoparticles can be synthesized through physical, chemical, and biological methods, those biologically synthesized demonstrate greater compatibility with human organs and tissues with minimum tissue rejection. Researchers have extensively explored the impact of size, shape, and synthesis method on their applications in biological systems. This review covers various synthesis methods, highlighting biosynthesis over various physical methods.